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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Here, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1This expression pattern was coordinated by target repression and promoter hypermethylation.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 130-136 doi: 10.15302/J-FASE-2014013

Abstract: In this study, using real-time quantitative RT-PCR, we investigated the expression pattern of and itsSmall white follicles were found to have significantly higher expression of and mRNA than any otherThe expression of and mRNA were detected in both granulosa and theca layers of pre-ovulatory follicles, the expression of in theca layers was slightly higher than in granulosa cells.These results indicate that the head-to-head genes of and exhibit similar expression in chicken follicles

Keywords： chicken     Vps36     Ckap2     mRNA     follicle    

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U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0880-8

Abstract: Estrogen regulates miRNA expression in a typical U-shaped dose-response pattern.Consistent U-shaped responses were seen in bodyweight, ventral prostate epithelial morphology, and miRNA expressionestradiol regulated miRNAs were downregulated at low doses of estradiol (0.2 and 2 mg·kg ), and whose expressionFurthermore, the miRNA-processing machinery, Drosha, in the prostate was also regulated in a similar pattern, which could be a part of the U-shaped miRNA expression mechanism.

Keywords： miRNA     Prostate     Estradiol     Nonmonotonic dose-response     Estrogenicity     Drosha    

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Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles

Miao Jiang, Cheng Xiao, Gao Chen, Cheng Lu, Qinglin Zha, Xiaoping Yan, Weiping Kong, Shijie Xu, Dahong Ju, Pu Xu, Youwen Zou, Aiping Lu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 219-228 doi: 10.1007/s11684-011-0133-y

Abstract: In the present study, we combine genome-wide expression analysis with methods of systems biology to identifyfunctional gene networks for the sets of clinical symptoms that comprise the major information for patternMicroarray technology was used to reveal gene expression profiles in CD4 T cells from 21 rheumatoidAlanine, aspartate, and tyrosine metabolism were related to cold pattern, and histindine metabolism andlysine degradation were related to hot pattern.

Keywords： gene expression profile     pathway     rheumatoid arthritis     traditional Chinese medicine     systems biology    

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Annotation and validation of genes involved in photosynthesis and starch synthesis from a

Yang ZHANG,Xin CHEN,Haiyan WANG,Zhiqiang XIA,Peng LING,Wenquan WANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 308-320 doi: 10.15302/J-FASE-2016113

Abstract: starch metabolism and photosynthesis were identified and five of them were selected to compare their expression

Keywords： Manihot esculenta     expressed sequence tag     unigene     pathway     expression pattern    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: This study aims to demonstrate that blocking the receptor-interacting protein2 (Rip2) expression canRip2 small interfering RNA (siRNA) plasmids were constructed and transfected into macrophage and Rip2 expressionRip2 siRNA plasmid could block the mRNA and protein expression of Rip2 and promote cell proliferationThe HMGB1 expression in the liver decreased to (40.21 ± 11.03) pg/g, and serum TNF-?The results demonstrate that Rip2 siRNA plasmid can block the expression of Rip2, decrease the production
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MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 99-103 doi: 10.1007/s11684-007-0019-1

Abstract: We detected loss of heterozygosity (LOH) and microsatellite instabilities (MSI), as well as extron expressionFour of 10 (40.0%) cases of primary GC showed absent or decreased expression of the FHIT protein as comparedThe findings in this study suggest that LOH and MSI of FHIT gene may induce aberrant extron expression
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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTBThe gene expression disparity between the GCTB samples and normal bony callus was significantly different

Keywords： giant cell tumor of bone     gene     microarray     cDNA    

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Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 361-367 doi: 10.1007/s11684-015-0395-x

Abstract: This study aimed to investigate the immunohistochemical expression of Mcl-1 in testicular biopsies of

Keywords： spermatogenesis     testis     Mcl-1 expression     immunohistochemical study     infertility    

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Construction of a universal recombinant expression vector that regulates the expression of human lysozyme

Shen LIU, Shengzhe SHANG, Xuezhen YANG, Huihua ZHANG, Dan LU, Ning LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 382-389 doi: 10.15302/J-FASE-2018211

Abstract: A key component in the technology is the construction of an efficient milk expression vector.Here, we established a simple method to construct a milk expression vector, by a combination of homologousThe highest expression level of rhLZ was 0.45 g·L−1, and rhLZ exhibited the sameOur results have provided a simple approach to construct a universal milk expression vector, and demonstratedthat the resulting vector regulates the expression of hLZ in milk.

Keywords： BAC recombinant methods     gene expression     human lysozyme     transgenic mice     milk expression vector    

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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 398-400 doi: 10.1007/s11684-007-0077-4

Abstract: The aim of this paper was to investigate the relationship between the expression of adrenomedullin (ADMThe expression of ADM was detected using immunohistochemical staining in specimens from 15 normal controlsThere was a positive correlation between the ADM expression and MVD in LE and LES respectively ( = 0.823The expression of ADM in LE was statistically lower than that in LES (<0.05).mitotic figures, the higher levels of the ADM expression and poor prognosis.

Keywords： anticarcinogenic     microvessel density     malignant potency     muscle     uterine leiomyosarcoma    

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Subsurface damage pattern and formation mechanism of monocrystalline -GaO in grinding process

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 2, doi: 10.1007/s11465-022-0677-3

Abstract: The aim of this study is to investigate the damage pattern and formation mechanism of monocrystallineof the grinding principle, revealing the mechanism of the mechanical effect of grits on the damage pattern

Keywords： monocrystalline beta-phase gallium oxide     grinding process     subsurface damage     nanocrystals     amorphous phase    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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SHIFTING TO A RECOMMENDED DIETARY PATTERN COULD PROMOTE SUSTAINABLE DEVELOPMENT OF THE ENVIRONMENT AND

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 1,   Pages 73-82 doi: 10.15302/J-FASE-2023489

Abstract: ItemContent>

● Shifting from the existing dietary patterns to the alternative recommended dietary pattern

Keywords： CHNS data     cluster analysis     dietary patterns     sustainable development    

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The influence of hand hole on the ultimate strength and crack pattern of shield tunnel segment joints

Shaochun WANG, Xi JIANG, Yun BAI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 5,   Pages 1200-1213 doi: 10.1007/s11709-019-0546-2

Abstract: A \ /-type crack pattern is always observed before the final failure of the segment joints.

Keywords： tunneling     structural synthetic fiber concrete     hand hole     segment joint     ultimate bearing capacity     crack pattern    

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Title Author Date Type Operation

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Journal Article

U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang

Journal Article

Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles

Miao Jiang, Cheng Xiao, Gao Chen, Cheng Lu, Qinglin Zha, Xiaoping Yan, Weiping Kong, Shijie Xu, Dahong Ju, Pu Xu, Youwen Zou, Aiping Lu

Journal Article

Annotation and validation of genes involved in photosynthesis and starch synthesis from a

Yang ZHANG,Xin CHEN,Haiyan WANG,Zhiqiang XIA,Peng LING,Wenquan WANG

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Journal Article

Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Journal Article

Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem

Journal Article

Construction of a universal recombinant expression vector that regulates the expression of human lysozyme

Shen LIU, Shengzhe SHANG, Xuezhen YANG, Huihua ZHANG, Dan LU, Ning LI

Journal Article

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Journal Article

Subsurface damage pattern and formation mechanism of monocrystalline -GaO in grinding process

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

SHIFTING TO A RECOMMENDED DIETARY PATTERN COULD PROMOTE SUSTAINABLE DEVELOPMENT OF THE ENVIRONMENT AND

Journal Article

The influence of hand hole on the ultimate strength and crack pattern of shield tunnel segment joints

Shaochun WANG, Xi JIANG, Yun BAI

Journal Article